The Marqués de Valdecilla University Hospital (HUMV) and the IDIVAL Health Research Institute are advancing in the multicenter clinical trial CASSANDRA, which evaluates in humans the experimental drug IDP-121, a direct cMyc inhibitor — a key protein involved in the development of most cancers.
This phase I/II study is aimed at patients with Multiple Myeloma, high-grade Non-Hodgkin Lymphoma, and Chronic Lymphocytic Leukemia, with the goal of determining the safety, tolerability, and preliminary clinical activity of this compound.
The trial is coordinated by Dr. Enrique M. Ocio, Head of the Hematology Department at HUMV and leader of the Hematology and Hemotherapy Group at IDIVAL. To date, seven patients have been enrolled in the dose-escalation phase, with no significant toxicities reported. Despite the low doses administered, a certain antitumor effect has been observed in some patients, achieving disease stabilization.
In parallel, complementary biological studies are being conducted at Valdecilla, coordinated by Dr. Santiago Montes, aiming to identify the mechanisms responsible for IDP-121’s activity and to better understand its molecular impact on these types of malignancies.
The CASSANDRA trial is being carried out in collaboration with four other Spanish hospitals: Vall d’Hebron Hospital (Barcelona), 12 de Octubre University Hospital (Madrid), University Hospital of Salamanca, and Virgen de la Arrixaca Clinical Hospital (Murcia).
This study represents a search for new therapeutic alternatives in hematologic oncology, particularly in diseases with limited options after multiple lines of treatment.
More information about the IDP-121-001 (CASSANDRA) clinical trial is available at clinicaltrials.gov (Identifier: NCT05908409).
