The Biomedical Research Institute Marqués de Valdecilla (IDIVAL) organizes the course “Introduction to Research Methodology” that will take place from the 16th to the 20th of October. This course is aimed at all the sanitary personnel of Cantabria with interest in health research.

With this training activity, IDIVAL wants to give to all professionals the necessary tools to take part in clinical research: the basic principles of study design, basic statistics, use of databases, resources available to support research and critical reading of articles.

Registration: 29 September – 8 October. 

Location: IDIVAL Assembly Hall. 

Duration: 20 hours, 4 hours per session, from the 16 to the 20 october 2017, from 4pm to 8pm.

Places available: 30.

Accreditation: Pending accreditation by the commission of continuing training of health professionals in Cantabria. A diploma of attendance will be provided to all attendees.

The course is free however, it is necessary to register through the IDIVAL website prioritizing applications by order of registration. Applications will be prioritized by order of registration. In case any interested person remaining outside the course, they will be prioritized for an upcoming edition.

Link for registration:

http://aplicacionesidival.idival.org/convocatorias/contenido/convocatorias.asp?TipoBeca=CURSOS&TituloTipoBeca=CURSOS

For any doubt or clarification you can contact us through the email gesval1@idival.org

Program of the Course (PDF)

IDIVAL organizes the course Introduction to Research Methodology

The Biomedical Research Institute Marqués de Valdecilla (IDIVAL) organizes the course “Introduction to Research Methodology” that will take place from the 16th to the 20th of October. This course is aimed at all the sanitary personnel of Cantabria with interest in health research. With this training activity, IDIVAL wants to give to all professionals the […]


Every year there are between 50,000 and 60,000 hip fractures with an annual incidence of 100 cases / 100,000 inhabitants in Spain. The most affected patients are usually elderly at about 80 years of age and three out of four are women.

Most hip fractures are solved with surgery as soon as possible. There are many studies that relate delayed intervention with increased mortality and morbidity.

Members of IDIVAL Nursing research group have just published a study carried out in the surgical area of Valdecilla Hospital to study a risk factor that has not been investigated to date: how patients with anticoagulant treatment (Sintrom® the most employed) they see the evolution of their affected prognosis. The main objective of this study was to study the possible relationship between the consumption of dicoumarinic agents (understanding the consumption of acenocoumarol as regulated and monitored anticoagulation) and the mortality rate in people older than 65 years undergoing a hip fracture (HF) intervention. 

The study concluded the consumption of acenocoumarol increased the risk of mortality within the first year after surgery in 1.3 of possible cases. Other risk factors that also independently increased the risk of mortality included advanced age, male sex, delayed surgery, the need for transfusions, and surgical risk (for high levels in the ASA classification).

Therfore, it could be suggested that early surgical intervention after hip fracture, as well as adequate anticoagulant control may contribute to reduce mortality in older people with hip fracture. Understanding the causes of increased patient mortality with these factors is posed as a future challenge that may help better clinical management.

Reference: Sarabia-Cobo CM, Sáenz-Jalón M, Vélez-Carrera B, Miguel Martín ME, Rodríguez Landeras G, Roscales San Bartolomé E, Santiago Fernández M, Higuero-Piris C, Artabe Pozas P, Espeso Salas S, Briz Casares S. Variables to Predict Mortality in Hip Fractures in Patients Over 65 Years of Age: A Study on the Role of Anticoagulation as a Risk Factor. J Trauma Nurs. 2017 Sep/Oct;24(5):326-334. doi: 10.1097/JTN.0000000000000313. PubMed PMID: 28885525.

Anticoagulation as a Risk Factor of mortality in patients with hip fractures

Every year there are between 50,000 and 60,000 hip fractures with an annual incidence of 100 cases / 100,000 inhabitants in Spain. The most affected patients are usually elderly at about 80 years of age and three out of four are women. Most hip fractures are solved with surgery as soon as possible. There are […]


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Unican



Human Resources Strategy for Researchers (HRS4R) is a tool adopted by the European Commission through the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter & Code), designed to promote equal rights and obligations for researchers throughout the European Research Area.

The aim of HRS4R is to promote the adoption of the 40 principles defined in the Charter & Code that delimit the rights and responsibilities of researchers and entrepreneurs.

The development of the strategy implies obtaining the “HR Excellence in Research” that recognizes the excellence and alignment of human resources policies with the lines established by the Commission, creating a stimulating and favorable working environment for researchers.

IDIVAL joined the Charter & Code in October 2016 (Initial Phase). Endorsement of the Charter&Code and Notification of Commitment.

Subsequently, IDIVAL developed the Implementation Phase preparing a “Gap Analysis” and an “Action Plan” for Human Resources Management. The institution carried out an initial assessment based on an exercise to identify gaps between its current policies and practices versus the 40 principles of the Charter and Code. The Action Plan describes what actions the organization will develop.

The following documents can be downloaded from the links below:

IDIVAL committed to the Human Resources Strategy for Researchers HRS4R

Human Resources Strategy for Researchers (HRS4R) is a tool adopted by the European Commission through the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter & Code), designed to promote equal rights and obligations for researchers throughout the European Research Area. The aim of HRS4R is to promote the […]


On the 5th of October an information session on “Health Financing Opportunities offered by the HORIZON 2020 program” will take place focusing on the opportunities planned for Social Challenge 1 (Teresa Corral, ISCIII) and on the legal and financial matter in H2020 (Gonzalo Arévalo, ISCIII).

At present, Carlos III Health Institute is organizing this type of event in all the autonomous communities presenting the new program 2018-2019, and of course, Cantabria has its own day.

This event is organized by the European projects unit of IDIVAL and the OPE of the Carlos III Health Institute. In addition, we will have the support of the European project offices of the University of Cantabria, IBBTEC, Santander City Council, CEOE, SODERCAN and the new office of European projects of the government of Cantabria. We are confident that this workshop will be of interest to our researchers and will help managers to keep up with the rules of participation.

The info day will be held on Thursday 5 October and will take place in the hall of Tower B of the Marqués de Valdecilla University Hospital which has a capacity for about 200 people. We would be grateful if you would reserve this date in your agendas and help us with the dissemination of the event among the members of your research group.

Provisional session program:

9:30 – 9:40   Welcome
9:40 – 10:40 Opportunities planned for Social Challenge 1 (Teresa Corral, ISCIII)
      10:40 – 11:00 Coffee break
      11:00 – 12:00 Legal and financial matters in H2020 (Gonzalo Arévalo, ISCIII)
      12:00 – 12:45 Experiences of success in Cantabria
      12:45 – 13:00 End of the session

Session will last about 3 hours and a half, starting at 9.30 and ending at 13.00.

We are very excited about this day and hope that it has a very good reception among the research community and encourage them to participate in European projects.

We would like to confirm your assistance in the following contact details:

Paloma González: Telephone number 942202857 or to the email innovacion4@idival.org


Info day Health financing opportunities in the H2020 program

On the 5th of October an information session on “Health Financing Opportunities offered by the HORIZON 2020 program” will take place focusing on the opportunities planned for Social Challenge 1 (Teresa Corral, ISCIII) and on the legal and financial matter in H2020 (Gonzalo Arévalo, ISCIII). At present, Carlos III Health Institute is organizing this type of […]


The European Researchers’ Night will be held on Friday, September 29, in the afternoon from 4.30pm until midnight. This event takes place simultaneously around 30 countries and over 300 cities.

For the fifth consecutive year, Santander joins this European event. Scientists from the University of Cantabria and associated institutions as the Biomedical Research Institute of Valdecilla (IDIVAL) will organize different activities around Santander: science workshops, talks, interactive scientific demonstrations, participatory experiments, guided tours, activities … adapted for people of all ages, interested in obtaining answers and in knowing the impact of scientific advances in everyday life.

Once again, IDIVAL participates in the event with 2 workshops, that they will take place at IDIVAL, and with a stand at the Plaza Porticada.

Workshop: What eye does not see. Microscopy as a tool

IDIVAL Microscopy unit will teach you and observe cells and microorganisms in different microscopes. You can see the different components of the cell in fluorescent colors and in three dimensions with the laser microscope, or the “hairs” of bacteria in the electron microscope.

In addition, we will explain how a time-lapse of a cell culture is made to see how they multiply and move.

This workshop will be held in the IDIVAL Building and is open to all the public who want to know the work we do.

Workshop: Know your body‘s defenses

We will experiment with techniques used in immunology (ELISA, cytometry, we will see lymphocytes in the microscope and in the cytometer). You can know how we isolate the cells and understand what we do and how we study the role of the components of the immune system that constitute body’s defenses. 

This workshop is aimed at children between the ages of 9 and 16 and will be held at IDIVAL.

All workshops require prior registration in the following link:

https://web.unican.es/unidades/cultura-cientifica/actividades/la-noche-de-los-investigadores

See you on Friday 29th!

More información: Link

One year more IDIVAL participates in the European Researchers Night

The European Researchers’ Night will be held on Friday, September 29, in the afternoon from 4.30pm until midnight. This event takes place simultaneously around 30 countries and over 300 cities. For the fifth consecutive year, Santander joins this European event. Scientists from the University of Cantabria and associated institutions as the Biomedical Research Institute of […]


Due to the success of the first edition of Santander Biomedical Lectures, on Thursday 28th of September will start the II Program of Conferences Santander Biomedical Lectures organized by the Cantabrian Health Service, the University of Cantabria (UC), the Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC) and Valdecilla Research Institute (IDIVAL).

The opening session will be given by Dr. Francisco Sánchez Madrid, Scientific Director of IIS-Princesa. The conference will focus on “Exosomes shuttling at the Immune Synapse: Mechanisms of microRNA and protein sorting”.

Francisco Sánchez Madrid is Scientific Director of the IIS-Princesa, Head of the Immunology Service and Professor at the University Hospital La Princesa. He began his research career at the Center of Molecular Biology “Severo Ochoa” addressing the biochemical and functional study of ribosomal proteins in eukaryotic organisms in the group of Dr. J. P. García Ballesta and David Vázquez.

He completed his postdoctoral stage in the group of Prof. Baruch Benacerraf (Nobel Prize 1980) at Harvard Medical School in Boston where he collaborated closely with Dr. Timothy A. Springer, identifying and characterizing the first families of leukocyte adhesion receptors of humans. These studies opened a new area of scientific research that transcended the discipline of Immunology to have an impact on cellular biology, and multiple medical specialties (Hematology, Rheumatology, etc).

In 1985, he began as an Independent Researcher in the Immunology Service of the Hospital La Princesa. Then, he directed a research group on the study of molecular mechanisms involved in and regulate the processes of adhesion, polarization, migration and leukocyte activation. His research area has expanded in recent years to the interactions of lymphocytes with endothelium, lymphocyte activation and chemokine-driven migration, as well as the role of adhesion and activation receptors, and dendritic cells in the initiation of immune response, immune synapse and regulation of the inflammatory response.

The conference will be open to the general public and it will take place on the 28th of September at Marques de Valdecilla University Hospital, Salon Tellez (Pavilion 16) at 8.15am.

Dr. Sánchez Madrid will be in Santander throughout the day, to exchange experiences with members of the scientific and clinical community. Furthermore, he will visit the Research Centers of our Community to talk with all the interested scientists.

Those professionals, who would like to meet with Dr. Sánchez during his stay, can contact with the department at gesval1@idival.org

Conference Santander Biomedical Lectures Thursday 28 September

Due to the success of the first edition of Santander Biomedical Lectures, on Thursday 28th of September will start the II Program of Conferences Santander Biomedical Lectures organized by the Cantabrian Health Service, the University of Cantabria (UC), the Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC) and Valdecilla Research Institute (IDIVAL). The opening session […]


Redacción Médica
The diagnosis of a joint prosthesis infection is based on a combination of clinical signs, laboratory tests, microbiological, histopathological, intraoperative and imaging studies. However, despite the availability of the various tests, none of them has absolute precision and the diagnosis of joint prosthetic infection remains a challenge. This relative difficulty in performing the diagnosis causes a significant effect on the prognosis of this type of infection.

Several investigations have evaluated the sensitivity and specificity of different tests for the diagnosis of infection associated with the implant, however, the individual or combined precision of the different tests had not been evaluated according to the time elapsed from the prosthetic implantation surgery to the diagnosis of infection associated with the implant.

The group of Epidemiology and Pathogenic Mechanisms of Infectious Diseases of the Institute of Sanitary Research-IDIVAL, coordinated by Dr. Carmen Fariñas, in the research area of ​​biofilms and prosthetic joint infections has recently published a study conducted by Dr. Marta Fernández Sampedro brings important knowledge in this field. The work has compared the precision both individually and in combination of the different diagnostic tests, such as culture of peri-implant tissue, sonic fluid, joint fluid, histopathology, C-reactive protein, for the diagnosis of infection acute (<3 months), subacute (3-12 months) and chronic prosthetics (> 12 months).

The results, which have been published in the journal BMC Infectious Diseases, show that, in addition to an infection associated with biofilm, in acute prosthetic infection the culture of sonicating fluid and peri-implant tissue reach the same sensitivity, without However, for subacute and chronic infection, the culture of sonicated fluid is the test that provides the highest diagnostic accuracy. When combining tests, such as histopathology and culture of peri-implant tissue, 100% of acute infections, 97% of subacute and 94.8% of chronic conditions are diagnosed. On the other hand, the combination of histopathology and culture of the sonicated fluid leads to a sensitivity of 100% to diagnose the three types of joint prosthesis infection.

Reference: Fernández-Sampedro M, Fariñas-Alvarez C, Garces-Zarzalejo C, Alonso-Aguirre MA, Salas-Venero C, Martínez-Martínez L, Fariñas MC. Accuracy of different diagnostic tests for early, delayed and late prosthetic joint infection. BMC Infect Dis. 2017; 17: 592.

What is the best diagnostic strategy in joint prosthesis infection

The diagnosis of a joint prosthesis infection is based on a combination of clinical signs, laboratory tests, microbiological, histopathological, intraoperative and imaging studies. However, despite the availability of the various tests, none of them has absolute precision and the diagnosis of joint prosthetic infection remains a challenge. This relative difficulty in performing the diagnosis causes […]


The UC-IDIVAL nanomedicine group has been working for several years in the design of nanomaterials and synthetic nano-structures in diagnostic and medical therapy. Recently, in collaboration with the group of Professor Miguel Correa-Duarte of the CINBIO Health Institute of Vigo, this research team has developed and characterized synthetic structures of morphology and size similar to viruses capable of penetrating into target cells and serving as vehicle for the administration of all types of therapies, including genetic therapies – such as DNA or RNA -, proteins, drugs or nanoparticles with therapeutic or diagnostic properties, and even combinations of these components.

The study led by Mónica López Fanarraga demonstrates that these nano-dispensers directed to target cells by ligand, are able to invade the cell/cytoplasm, protecting the encapsulated content inside and releasing it in the cytoplasm after the disassembly of the nanostructure and subsequent degradation of its components in fully biocompatible products. This nano biotechnological engineering design, currently protected by the patent ES 2577056 B2, represents a step further in the application of therapies directed to the intracellular level and will allow in the future to be able to work specifically in the different cellular compartments, not only at the therapeutic level but by controlling and evaluating real-time processes in living cells.

References:

“A synthetic getaway biomimetic strategy for cytoplasm particle invasion” Angew Chem Int Ed Engl. 2017 Sep 5. doi: 10.1002/anie.201707769

“Carbon nanotubes gathered onto silica particles lose their biomimetic properties with the cytoskeleton becoming biocompatible” International Journal of Nanomedicine, 2017:12, 6317—6328

 

New synthetic nanostructures capable of penetrating in target cells

The UC-IDIVAL nanomedicine group has been working for several years in the design of nanomaterials and synthetic nano-structures in diagnostic and medical therapy. Recently, in collaboration with the group of Professor Miguel Correa-Duarte of the CINBIO Health Institute of Vigo, this research team has developed and characterized synthetic structures of morphology and size similar to […]