Aim: To make known the fundamentals of optical and electronic microscopy, as well as the theoretical and practical bases of the preparation of biological samples to optimize the obtaining of images by means of these technologies. Analyze and present results.

Addressed to: graduates and technicians in health sciences and pre and post-doctoral research staff.

Venues:

  • Sessions I, II and V in the IDIVAL building. Av. Cardenal Herrera Oria s / n – Santander
  • Session III. Department of Anatomy and Cell Biology. Faculty of Medicine of Cantabria. Av Cardenal Herrera Oria 2- Santander
  • Session IV. Computer classroom. HUMV Library 2nd floor pavilion 16. Av. Valdecilla s / n – Santander

Dates: November 4-8, 2019

Hours: 4:00 p.m. to 8:00 p.m.

Duration: 20 hours

Methodology: Theoretical – practical

Number of places: 14 students

Registration deadline: From October 1 to 25, 2019

Fees: 200 euros

Course accredited by the Commission for Continuing Education of the Health Professions of Cantabria

Registration procedure

Access through the link: https://idival.org/es/Portal-de-Formaci%C3%B3n

Access to program here.

More information:

  • e-mail: microscopia2@idival.org
  • Phone: 942 31 55 15 – Ext .: 73217

After the success achieved in the previous cycles of the Santander Biomedical Lectures sessions, the speakers of the fourth cycle of conferences composed of prestigious researchers recognized worldwide for their international contributions are presented.

For the consecutive year the Cantabria Research Forum, integrated by the Cantabrian Health Service together with the Valdecilla Research Institute (IDIVAL), the University of Cantabria (UC) and the Cantabria Biomedicine and Biotechnology Institute (IBBTEC) has opted for create this discussion forum on the current advances in biomedicine, bringing reference researchers to exchange experiences with members of the scientific and clinical community of our region.

Following the trail of previous years, this IV cycle of sessions will focus on a series of conferences dedicated to the advancement of global knowledge in Biomedicine.

The conference venue, which will be open to all Santander public who wants to participate, will be the Marqués de Valdecilla University Hospital in the Téllez Hall (Hall 16) at 8.15 hours. Then the speakers will remain in our community for at least a few hours to visit the research centers of our community to meet first-hand the interested scientists.

Presentation of the IV Cycle of the Santander Biomedical Lectures sessions

After the success achieved in the previous cycles of the Santander Biomedical Lectures sessions, the speakers of the fourth cycle of conferences composed of prestigious researchers recognized worldwide for their international contributions are presented. For the consecutive year the Cantabria Research Forum, integrated by the Cantabrian Health Service together with the Valdecilla Research Institute (IDIVAL), […]


The PRIM-VAL grants are part of the IDIVAL grants program that are contemplated in the IDIVAL Valdecilla 2018 Biosanitary Strategic Dynamism Program.

The Program to support research projects in primary care (PRIM-VAL) aims to promote innovation and research in primary care.

According to the bases of the Valdecilla Biosanitary Dynamism Program published on the IDIVAL website, once the projects admitted for evaluation are evaluated, the following researchers and their projects are granted funding.

Researcher   Amount Granted 
 Alberto Elices Gorostiaga  € 10,000
 Teresa Tigera Calderón  € 10,000

Its execution is subject to IDIVAL project management instructions.

The principal investigators of the projects have 7 days to waive the granting of the aid, before it becomes final.

Resolution (download pdf)

More information: Prim-Val aids (link)

Resolution of the concession of PRIM-VAL grants 2019

The PRIM-VAL grants are part of the IDIVAL grants program that are contemplated in the IDIVAL Valdecilla 2018 Biosanitary Strategic Dynamism Program. The Program to support research projects in primary care (PRIM-VAL) aims to promote innovation and research in primary care. According to the bases of the Valdecilla Biosanitary Dynamism Program published on the IDIVAL […]


The multidisciplinary research group of nanomedicine-IDIVAL belonging to the NanoBioAp network (@NanoBioAp) has just won two research projects in the AES2019 call (PI19 / 00496 and DTS19 / 00033). Their objective is to develop a precision system for the diagnosis and non-invasive therapy of head and neck cancer.

It is estimated that the incidence is about 11,000 cases / year in Spain. Currently, the diagnosis is carried out by physical examination and confirmed by endoscopy and imaging tests. Approximately 35% are diagnosed in localized stages, 55% as locally advanced and 10% in the form of systemic metastases and the stage at the time of diagnosis is associated with survival. In standardized epatas the standard treatment is surgery and in the locally advanced multimodal treatment with the integration of chemotherapy and radiotherapy. 

Despite advances in recent years, 5-year survival is around 30-55% in locally advanced tumors, so early arrest will be associated with a considerable increase in survival. These projects will focus on the development of nanoparticles (NP) of the size of the virus, which will specifically recognize cancer cell receptors, allowing their early detection and penetrating them to activate their destruction from within after being activated by light. This project is completed with the development of a fibroscope type system, which will be used for (i) the diagnosis of lesions in a traditional way (white light), (ii) the precise detection of tumor and precancerous cells, both identified by Fluorescent NPs (identified with blue light) and (iii), finally, to activate their destruction by photoinduced hyperthermia with infrared light. The versatility of the design of these nanodevices will allow, by making minor modifications, to be applied to many types of cancer accessible topically. 

These projects are only viable thanks to the close collaboration of clinical researchers, pathologists, molecular / cellular biologists, pharmacists, physicists and chemists who, since 2013, coordinate their know-how for the development of new technologies in the fight against cancer.

Group websites:

Granting of two projects of the Health Research Fund FIS to the Nanomedicine group

The multidisciplinary research group of nanomedicine-IDIVAL belonging to the NanoBioAp network (@NanoBioAp) has just won two research projects in the AES2019 call (PI19 / 00496 and DTS19 / 00033). Their objective is to develop a precision system for the diagnosis and non-invasive therapy of head and neck cancer. It is estimated that the incidence is […]


We are pleased to announce that Cantabria (Marqués de Valdecilla Health Research Institute, IDIVAL) has been awarded ONE star as a result of the 2019 Call for Reference Sites of the European Innovation Partnership of Active and Healthy Ageing (EIP on AHA).

Cantabria (Marqués de Valdecilla Health Research Institute, IDIVAL) will join a total of 77 regional and local organisations that have demonstrated the existence of comprehensive strategies to advance innovation and to understand and address the challenges of delivering health and care services to the ageing population. They successfully bring together a wide range of stakeholders based on a “Quadruple Helix” model that includes representatives from industry, civil society, academia and government authorities at a regional and local level. These collaborations drive structural change far beyond the scope any one particular organisation could achieve on its own, helping to create an environment for other regions across Europe to learn, transfer and adapt knowledge to local realities, with regional, social and economic development as the long-term objective.

The Reference Site status has been granted to those organisations who have shown excellence in the development, adoption and scaling up of innovative practices for active and healthy ageing. This work should also be aligned with the strategic objectives of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) and the relevant new strategic developments including the Transformation of Health and Care in the Digital Single Market and work carried out through the Horizon 2020 WE4AHA CSA, particularly in the 3 horizontal initiatives, such as the Blueprint and the Innovation to Market (I2M) plan and MAFEIP.

For the first time, as a result of the peer-review and expert review process in the 2019 Call, six 4 star reference Sites have been awarded a “Special recognition for excellence” for their outstanding work in driving regional innovation in active and healthy ageing, improving the quality of life of the ageing population, making health and social care delivery more sustainable and stimulating economic growth and competitiveness. These Reference Sites include: South Denmark, Basque country, Andalusia, Catalonia, HANNN and Scotland. 

However, this is only the beginning. The EIP on AHA provides a framework for continuous improvement and the involvement of new relevant stakeholders to enable any Reference Site to maintain and further improve its status. The process for becoming or making progress as a Reference Site incorporates an Improvement Tool which Reference Sites can use to identify gaps and opportunities for improvement, as well as develop an implementation plan. This will allow Reference Sites to continually challenge and benchmark themselves to ensure they are at the forefront in strategy and policy development and therefore contributing to the economic growth in their region and across Europe.

For more information about the European Innovation Partnership of Active and Healthy Ageing: https://ec.europa.eu/eip/ageing/home_en


The research project led by Dr. López Hoyos (Transplant and Autoimmunity group) entitled “Prevalence of post-transplant solid organ non-alcoholic steatohepatitis. Involvement of the innate and adaptive immune response” has obtained funding from the Carlos III Health Institute in the last call of the recently resolved National Plan.

The prevalence of fatty liver disease (NAFLD) is increasing exponentially in our environment, largely associated with the lifestyle of obesity and diabetes. A small percentage will develop non-alcoholic steatohepatitis (NASH) with the associated risk of fibrosis and progression to liver failure that will necessitate liver transplantation. NASH has become an increasing indication of liver transplantation, surpassing even alcoholic liver disease. 

The incidence of NAFLD and its progression to NASH may be increased in liver transplants, but also in another type of solid organ transplant where it has not been taken into account to date. This increase may be conditioned by classic risk factors of metabolic NAFLD (insulin resistance, accumulation of short chain fatty acids, oxidative stress and mitochondrial dysfunction). All of them, together with a pro-inflammatory state, converge in a “multiple hit” that contributes to liver damage and inflammation. 

In the context of solid organ transplantation, a pro-inflammatory state dependent on the allogeneic response coexists against the graft counteracted by the immunosuppressive therapy administered. An alteration of this balance towards an inflammatory state can favor the development of NASH independent of the classic metabolic picture. The definition of phenotypic and functional profiles of the immune response in long-term solid organ transplants with NASH and differentiated clinical phenotypes (with metabolic syndrome or not) can help identify immunological factors related to liver damage risk and its involvement with treatment. immunosuppressant The funded work aims to investigate the role of fatty liver in all types of solid organ transplantation and detect possible immunophenotypes that allow differentiating a different progression. The work team is multidisciplinary and combines expert clinical researchers in the field of transplantation together with researchers with a more basic profile (immunologists) and epidemiologists that facilitates the possible translation of the expected results.

The work is part of the group's strategy of “individualizing” drug immunosuppression. Thus, the finding of immunological profiles associated with the development of NAFLD and its relationship with the different immunosuppressants received may contribute to this individualization and may even allow new therapeutic approaches. In addition, the study of soluble populations and mediators of the blood immune response is likely to identify biomarkers of clinical utility in the management of the development of NAFLD and NASH in transplant patients. The thematic will allow to advance in the line of work of the multidisciplinary group in NAFLD and NASH that has begun to work in the Marqués de Valdecilla University Hospital.



Concession of a Health Research Fund FIS project to the Transplant and Autoimmunity group

The research project led by Dr. López Hoyos (Transplant and Autoimmunity group) entitled “Prevalence of post-transplant solid organ non-alcoholic steatohepatitis. Involvement of the innate and adaptive immune response” has obtained funding from the Carlos III Health Institute in the last call of the recently resolved National Plan. The prevalence of fatty liver disease (NAFLD) is […]


Surgeons at the Marqués de Valdecilla University Hospital (HUMV) have developed, with the advice of the IDIVAL Innovation Support Unit that belongs to the ITEMAS Platform, an arc-shaped device that allows surgery performed in the pelvis at the same time that are operated, with robotic assistance, pathologies in the organs of this same part of the body. Above all, it is useful for treating local tumors in advanced stages.

Simultaneously combining the two surgeries is complicated because anatomically it is difficult to identify the different surgical planes. The device facilitates this differentiation from previously taken resonance images.

In addition, as explained by Dr. Marcos Gómez, a colorectal surgeon at the Valdecilla Hospital, the new device also ensures a “greater cleaning” when removing the tumor from the pelvis (a more radical surgery that eliminates any trace of cancer in the affected zone).

For Rubén Martín Láez, Head of Neurosurgery at the Hospital de Valdecilla, the advantages of the device are two: Keep the coordinate system fixed by anchoring the patient to the surgical table to avoid displacement and thus enable reliable navigation, put that surgery with intraoperative imaging can be performed in real time (knowing at every moment where the tip of the instrument being used is located).

The device has been developed in collaboration with the engineering company Developia and with the advice of the Innovation Support Unit of IDIVAL.

This digitized surgery allows augmented reality applications to be incorporated into robotic surgery. Another advantage of transanal robotic surgery is post-surgical recovery times with significantly shorter hospital stays.

The path to the automation of surgery goes through navigation systems that allow surgical robots to orient themselves in the space and anatomy of each patient. Navigation systems such as the one presented by the Marqués de Valdecilla University Hospital (HUMV) will allow these future developments.


The European Commission has extended the deadline for participation in the public consultation aimed at co-designing the implementation of the future Framework Program for Research and Innovation, Horizon Europe. Before participating in the consultation it is recommended to read the attached document: “Orientations towards the Implementation Strategy of the research and Innovation framework program Horizon Europe” to know the initial implementation strategy designed by the Commission. All those interested in the future of research and innovation in the EU, and citizens in general, are encouraged to participate in the consultation, whose deadline has been extended until October 4.

Access to public consultation

If you are interested in participating in this call, do not hesitate to contact the International Projects Office of IDIVAL and they will advise you. Contact email: innovacion4@idival.org or projects1@idival.org


PUBLIC CONSULTATION ON THE IMPLEMENTATION OF THE STRATEGIC PLAN FOR HORIZONTE EUROPE

The European Commission has extended the deadline for participation in the public consultation aimed at co-designing the implementation of the future Framework Program for Research and Innovation, Horizon Europe. Before participating in the consultation it is recommended to read the attached document: “Orientations towards the Implementation Strategy of the research and Innovation framework program Horizon […]


Background and objective

The Pulmonary Hypertension Unit of the Marqués de Valdecilla University Hospital of Santander is one of the most experienced units in Spain, along with the Hospital October 12, Madrid and the Hospital Clinic of Barcelona and concentrates an important clinical and research activity in this field.

The Pulmonary Hypertension Unit is led by the Pulmonology Service, a reference National lung transplant. Multiple services participate in the HAP Unit those that highlight the Cardiology Service with the Imaging Unit (echocardiography, Magnetic Resonance) and the Hemodynamics Unit, the Rheumatology Service with extensive experience in systemic diseases, the Pharmacy Service, the Service of Radiology, the Digestive Service, the Pharmacy Service and the medical-surgical team of the Pulmonary Transplant program, among others.

This Unit develops an intense teaching activity in Pulmonary Hypertension, having completed at least 10 editions of theoretical and practical courses of Hypertension Pulmonary focal raised in national professionals dedicated to PAH.

The objective of the program is to expand knowledge and skills in hypertension pulmonary for which it is proposed to hold a monthly meeting on the second Thursday of each month from 4:00 p.m. to 6:30 p.m.

Formative Meetings

Theoretical and clinical training will take place every month that will cover the following topics:

  • Definition, classification and epidemiology of pulmonary hypertension.
  • Function and adaptation of the right ventricle in pulmonary hypertension.
  • Genetics of pulmonary arterial hypertension.
  • Diagnostic algorithm and prognostic assessment in pulmonary hypertension
  • Non-invasive imaging techniques in pulmonary hypertension: echocardiography, resonance Cardiac and CT.
  • Right heart catheterization and pulmonary arteriography.
  • General measures and conventional treatment. Pregnancy and contraception. Rehabilitation.
  • Nitric oxide pathway and PDE-5 inhibitors. Antagonists of the receptors of the endothelin Stimulators of guanylate cyclase.
  • Prostacycline analogs and prostacycline IP receptor agonists.
  • Treatment for objectives in pulmonary hypertension
  • Pulmonary / cardiopulmonary transplant and atrial septostomy
  • Idiopathic pulmonary arterial hypertension.
  • Pulmonary hypertension associated with toxic rapeseed oil.
  • Pulmonary Venoocclusive Disease
  • Pulmonary hypertension associated with connective tissue diseases
  • Pulmonary hypertension associated with HIV and portopulmonary.
  • Pulmonary hypertension associated with congenital heart disease in adults.
  • Pulmonary hypertension in pediatrics.
  • Follow-up of the patient with pulmonary thromboembolism. Hypertension Treatment chronic thromboembolic lung.
  • Pulmonary hypertension in chronic respiratory pathology
  • Pulmonary hypertension in left heart disease.

Calendar of Formative Meetings (OCTOBER 19-DECEMBER-19)

  • Venue: training room nº7, pavilion 16, 2nd floor. HUMV
  • Hours: 16:00-18:30h

OCTOBER 10, 2019: Risk measurement in pulmonary hypertension (echocardiography, ergometry)

NOVEMBER 14, 2019: Clinical trials in Pulmonary Hypertension.

DECEMBER 12, 2019: Bibliographic session of Pulmonary Hypertension.


Frequently in the Spanish hospitals, the personnel in charge of the patients who enter the hospital find difficulties at the time of discharge, which extend the stay and are not due to clinical complications but to family or social factors. Generally, the patients, already older and in need of help in their self-care, need to adapt their family life or environment, staying additional days of hospital stay. Known for different terms, such as bed-blocking, high delayed, long stay, etc., it is a problem widely studied in health systems such as the British, but little in our country.

In a recent publication of the “International Journal of Environmental Research and Public Health” the results of a study carried out at the Marqués de Valdecilla University Hospital (HUMV), on cases of delayed discharge in the period between 2007 and 2015.

The study, which won the Valdecilla Nursing Research Award in the 2016 call, funded by IDIVAL, was carried out by a multidisciplinary team of clinical professionals, economists, lawyers and managers from Asturias and Cantabria. The authors wanted to describe the impact of the phenomenon in Cantabria, relating the prolongation of the stay with the patient's own factors such as age, gender or problem by which he enters and also with issues related to the organization of care. In addition, progression has been observed throughout the study period, coinciding with the implementation of the dependent care system and the recent economic crisis.

According to the results of the study, 3015 cases of delayed discharge in the HUMV have been found in those years. The total stays in these cases generally triple the usual average hospital stay. Although it is not an exclusive problem for the elderly, it is usually elderly patients, affecting men and women equally. The longest extension of the stay is related to cases of high complexity, which usually require surgical intervention and need a subsequent admission to the hospital in a functional recovery center before returning home or to a definitive residence. Given the progression throughout the study period, after a rebound in 2008, there is a tendency to improve both in fewer cases and in shorter stays. According to the authors, this may reflect the positive effect of the implementation of the system of care for dependents in the region, the impact of the crisis on a greater availability of caregivers or even on the awareness of health care providers towards the efficiency of resources they handle, such as the days of hospital stay.

The study highlights the joint work between different disciplines to investigate a problem that not only generates an economic expense, but also favors a greater risk of complications during those unnecessary days of stay and a suffering for the patient who suffers and their families. In that direction, the work of the research team on the subject will continue.

Pellico-López A, Cantarero D, Fernández-Feito A, Parás-Bravo P, Cayón de las Cuevas J, Paz-Zulueta M. Factors Associated with Bed-Blocking at a University Hospital (Cantabria, Spain) between 2007 and 2015: A Retrospective Observational Study. Int. J. Environ. Res. Public Health. 2019 Sep 9;16 (3304). doi:10.3390/ijerph16183304.

Deliberately multidisciplinary why we need new visions for the usual problems

Frequently in the Spanish hospitals, the personnel in charge of the patients who enter the hospital find difficulties at the time of discharge, which extend the stay and are not due to clinical complications but to family or social factors. Generally, the patients, already older and in need of help in their self-care, need to […]