Sorafenib is the principal (and until recently the only) first-line systemic treatment for patients with advanced hepatocellular carcinoma (HCC). Despite having been shown to improve survival in 2 randomized clinical trials compared with placebo [Llovet JM et al. N Engl J Med. 2008; 359: 378-90 and Chen A-L et al. Lancet Oncol. 2009; 10: 25-34] […]
Some 40 years since CT scans first revealed abnormalities in the brains of schizophrenia patients, we can now say, that in general (not all patients have) the disorder is a systemic disruption to the brain's entire communication system. This week, the Nature journal Molecular Psychiatry published the largest analysis of “white matter” (fatty brain tissue […]
Guillain-Barré syndrome (GBS) is an immune-mediated cause of acute neuromuscular paralysis. During the last three decades, the Neurology Service (University Hospital Marques de Valdecilla), collaborating with the Clinical Neurophysiology, Radiology, Pathological Anatomy, and the Department of Anatomy and Cell Biology of the University of Cantabria (UC) have done epidemiological, clinical-pathological and nerve ultrasound investigations in […]
Every year there are between 50,000 and 60,000 hip fractures with an annual incidence of 100 cases / 100,000 inhabitants in Spain. The most affected patients are usually elderly at about 80 years of age and three out of four are women. Most hip fractures are solved with surgery as soon as possible. There are […]
The diagnosis of a joint prosthesis infection is based on a combination of clinical signs, laboratory tests, microbiological, histopathological, intraoperative and imaging studies. However, despite the availability of the various tests, none of them has absolute precision and the diagnosis of joint prosthetic infection remains a challenge. This relative difficulty in performing the diagnosis causes […]
The UC-IDIVAL nanomedicine group has been working for several years in the design of nanomaterials and synthetic nano-structures in diagnostic and medical therapy. Recently, in collaboration with the group of Professor Miguel Correa-Duarte of the CINBIO Health Institute of Vigo, this research team has developed and characterized synthetic structures of morphology and size similar to […]
With an expenditure that currently exceeds oncological and cerebrovascular pathology together, and an exponential increase in the number of cases, dementias are the main challenge facing our socio-health systems. Although we do not yet have treatments that modify the course of these diseases in the last decade, there has been much progress in its diagnosis. […]
Studies developed at the University Hospital Marqués de Valdecilla help to detect early infection in these patients. Despite the significant progress made in recent years, lung transplantation is a solid organ transplant that has the shortest life expectancy. In part this fact is due to complications that occur in the first postoperative days of the […]
IDIVAL’s Clinical and Molecular Microbiology group has published a study that analyzes the survival of bacteria of the genus Acinetobacter on some of the most used surfaces in hospitals. The persistence of pathogenic bacteria in hospitals and health centers plays an important role in the onset of outbreaks and hospital-acquired infection. These bacteria survive in […]
IDIVAL's Clinical and Molecular Microbiology group has participated in a study about the evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone. Pseudomonas aeruginosa chronic respiratory infection (CRI) is the main driver of morbidity and mortality in patients suffering from cystic fibrosis (CF). The CF respiratory tract is a dynamic, heterogeneous, […]
